Education and Professional Experience
Virgilio Pace is graduate in veterinary pathology (DVM). He is Diplomate of the European College of Veterinary Pathology, and Fellow of the Academy of Toxicological Pathology. He is Registered Toxicologist of the Swiss Register of Toxicologists.
Virgilio Pace started his career in Life Science Research (a UK based CRO) with a subsidiary in Rome where he was mainly working as pathologist, head of pathology and trainee toxicologist. After few years in the CRO, he moved to Switzerland with Ciba-Geigy and subsequently with Novartis. In Novartis he became head of the pathology laboratories as well as project team representative responsible for the toxicology development of a successful renin-inhibitor that reached the market. In Novartis he was also internal consultant for the oncology therapeutic area (serving as experimental pathologist).
In 2002 he left Novartis to become head of preclinical development by Dompé farmaceutici in Italy. In this position, he brought 5 new products in clinic (2 are currently in clinical phase 2 and two new biological entities are in the process of MAA).
In 2000, Virgilio Pace received the Award from European Society of Toxicological Pathology for the best publication of the year.
Major publications:
Pace V., Persohn E., Heider K.: Spontaneous osteosarcoma of the meninges in an albino rat. Vet Pathol 32:204-207, 1995;
Pace V., Heider K., Persohn E., Schaetti Ph.: Spontaneous malignant cranialpharyngioma in an albino rat. Vet Pathol 34:146-149, 1997;
Pace V.: Spontaneous choroid plexus carcinoma in an albino rat. Exp Toxic Pathol 50:225-228, 1998;
Pace V., Mahrous AT., Perentes E.: Pulmonary vascular sclerosis in an albino rat with leukemia. Exp Toxic Pathol 52:308-311, 2000;
Pace V., Perentes E.: Mixed pituitary adenoma-gangliocytoma in a female albino rat. Acta Neuropathologica 101:277-280, 2001;
Pace V., Perentes E., Germann PG.: Pheochromocytomas and ganglioneuromas in the aging rats: morphological and immunohistochemical characterization. Toxicological Pathology 30(4): 492-500, 2002;
Pace V., Scarsella S, Perentes E.: Parathyroid gland carcinoma in a Wistar rat. Veterinary Pathology 40:203-206 (2003);
Hill G., Pace V., Persohn E., Bresser C., Haseman J, Tischler A., Nyska A.: A Comparative Immunohistochemical Study of Spontaneous and Chemically Induced Pheochromocytomas in B6C3F1 Mice, Endocrine Pathology 14 (1):81-92, 2003
Author of Classic Examples in Toxicologic Pathology. European Society of Toxicologic Pathology: Inhibitors of Matrix Metalloproteinases, 2005;
Carlo-Stella C., Di Nicola M., Longoni P., Cleris L., Gavazza C., Dilani R., Milanesi M., Magni M., Pace V., Colotta F., Avanzino MA., Formelli F., Gianni AM. Placental growth factor-1 potentiates hematopoietic progenitor cell mobilization induced by granulocyte colony-stimulating factor in mice and non-human primates. Stem Cells, September 28, 2006.
Ohno N. Terada N., Komada M., Saitoh S., Costantini F., Pace V., et al. Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localisation of TSLC1. Biochimica et Biophysica Acta 1793 (2009) 506-515;
Pace V., Wieczorek G., et al. Spontaneous Metastatic Angiosarcoma of the Tongue in a Wistar Rat: Morphological and Immunohistochemical Characterization. Toxicologic Pathology, 38: 472-475, 2010.